科研项目: 1.国家自然科学基金青年基金项目《新型鸭嘴花碱类二聚体多靶点抗AD配体的设计、合成及生物活性》 2.河南省科技厅科技攻关项目《脱氧鸭嘴花酮碱-苄基哌嗪衍生物多靶点抗老年痴呆及作用机制研究》 学术论文: 1.Hongtao Du; Fang Ma; Yuanyuan Cao, et al. Bis(7)-harmine derivatives as potential multi-target anti-Alzheimer agents. Frontiers in Chemistry, 2025, 13: 1545908. 2.Hongtao Du; Jinzhi Song; Fang Ma, et al. Novel harmine derivatives as potent acetylcholinesterase and amyloid beta aggregation dual inhibitors for management of Alzheimer’s disease, Journal of Enzyme Inhibition and Medicinal Chemistry, 2023, 38(1): 2281893. 3.Song Xinqiang; Zhang Yu; Du Hongtao. Molecular mechanism of celastrol in the treatment of systemic lupus erythematosus based on network pharmacology and molecular docking technology, Life Sciences, 2020, 117063. 4.Hongtao Du; Xinlian Liu; Jusen Xie, et al. Novel deoxyvasicinone-donepezil hybrids as potential multitarget drug candidates for Alzheimer's disease, ACS Chemical Neuroscience, 2019, 10(5): 2397-2407. Ma, Fang; Du, Hongtao, Novel deoxyvasicinone derivatives as potent multitarget-directed ligands for the treatment of Alzheimer's disease: Design, synthesis, and biological evaluation, European Journal of Medicinal Chemistry, 2017, 140: 118-127. |